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Institut Curie Reportage Cell Action
PSCC_fond bleu

CellAction

Cell Therapy Acceleration and Innovation

Heads:

1. Dr. Marion Alcantara; 2. Dr. Sebastian Amigorena

Objectives

• Offering a collaborative platform that engages partners at every stage: research, preclinical and translational.
• Bridging the gap from scientific concept to product development.
• Developing GMP-ready products.
• Understanding modes and mechanisms.

Operator (s)

Technology and expertises

Pre-GMP cell & gene therapy development

• Highly qualified technical and scientific team

• Integrated clinical expertise

• Pre-GMP environment

In vitro and in vivo PoC analyses


Facilities and activities
  • Pre-GMP CAR-T cell engineering and manufacturing
    Technology highlights: CliniMACS Prodigy platform / GMP-compliant electroporators

  • Analytical development
    Technology highlights: MACSQuant cytometer / digital PCR (Nio(r))

  • In vitro PoC
    Technology highlights: Lumicks z-Movi cell avidity analyzer, xCELLigence RTCA eSight real-time live cell analyser, spectral flow cytometry platform, single-cell omics (10X Genomics), Jess automated Western blot (Bio-Techne)

  • In vivo PoC
    Technology highlights: Xenograft and syngeneic tumor models, imaging (bioluminescence, fluorescence), stereotaxic neurosurgery, ex vivo analyses (flow cytometry, IHC, IF)

CellAction from the Institut Curie brings expertise and cutting-edge technologies

 to provide a complete solution for GMP-compliant cell engineering and scalable

 manufacturing for clinical testing, bringing a new momentum for innovative clinical trials.

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