AMMICa Core Facilities Platform
Single Cell, Genomic and Spatial Biology
Heads:
Dr. Nathalie Droin; Pr. Cécile Badoual
Objectives
Identification and characterization of different cell types and tissue regions associated with diseases to guide the discovery of potential therapeutic drugs.
Operator (s)
Technology and expertises
Single-cell multi-omics for high resolution analysis of cell-to-cell variation in a complex multicellular environment.
Spatial transcriptomics and proteomics for spatial localization of RNA molecules and proteins in tissues at cellular resolution.
Services and activities
Nucleic Acid Preparation for Genomic Analyses
Technology highlight: Ionic DNA/RNA extraction system (Bionano).
Genomics and Single Cell Genomics by Next Generation Sequencing
Technology highlights: NovaSeq6000, MiSeq, NextSeq2000 (Illumina), Promethion (Oxford Nanopore technologies), Tapestri (MissionBio), Chromium (10X Genomics).
Multi-OMICS Spatial Biology Analyses (PETRA, PFIC)
Technology highlights: Ultra Spatial Imaging Merscope ISH-based system (Vizgen), Visium CytAssist Probe-based systems (10X Genomics), COMET spatial proteomics system (Lunaphore).