P1
CellAction Platform
Cell Therapy Acceleration
and Innovation, Cell and Gene Therapies
Heads:
1. Dr. Marion Alcantara;
2. Dr. Sebastian Amigorena.
Objectives
Offering a collaborative platform that engages partners at every stages: research, preclinical, and translational.
Bridging the gap from a scientific concept to product development.
Developing GMP-ready products.
Understanding the modes and mechanisms.
Opérateur (s)
Technology and expertises
Pre-GMP cell & gene therapy development
• Highly qualified technical and scientific team
• Integrated clinical expertise
• Pre-GMP environment
In vitro and in vivo PoC analyses
Facilities and activities
Pre-GMP CAR-T cell engineering and manufacturing:
Technology highlights:
CliniMACS, Prodigy platform, GMP-compliant electroporators.
Analytical development:
Technology highlights:
MACSQuant cytometer / Nio(r) Digital PCR.
In vitro PoC:
Technology highlights:
Lumicks, z-Movi cell, avidity analyzer, xCELLigence RTCA, eSight Real-time live cell analyser, spectral flow cytometry platform, single-cell omics (10XGenomics), Jess automated, Western Blot (Bio-Techne).
In vivo PoC:
Technology highlights:
Xenograft and syngeneic tumor models, imaging (bioluminescence, fluorescence), stereotaxic neurosurgery, ex vivo analyses (flow cytometry, IHC, IF).
